LWE: Extract the blue stained area appearing on eyelid images
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LWE (Lid Wiper Ephithelium) is a software product that lets the user automatically extract the blue stained area appearing on eyelid images, and compute automated image-processing derived metrics in a sample comprising subjects with a range of LWE.
For LWE to generate accurate measurements, the upper lid margin needs to be stained with lissamine green (LG) dye using an optimized procedure to detect LWE. To reduce blur and improve depth of field, three images focused on the central, temporal and nasal regions of each upper lid are captured at 12x magnification through a digital camera (Canon EOS 60D) attached to a slit-lamp with constant camera settings maintained during the study. Using LWE, each set of 3 images is automatically registered and processed and metrics characterizing the stained area are computed. To validate the LWE Software, all images that were originally captured were also graded by an investigator using a 0-3 scale (Korb et al. Eye Contact Lens, 2005). Mean difference, correlation, generalized linear model (GLM), and ROC analyses were undertaken using basic statistical analysis.
During software development and validation phases, researchers characterize a number of aspects of LWE using this custom software.
Three categories of users are available in LWE: Viewer, Grader and Trainer.
LWE is a stand-alone, software product that can be installed on any personal computer running Windows® XP or higher.
Video TutorialsLWE Grader